<P>4 TULANE | MEDICINE FALL 2013 tulane.edu/som MEDICINE NEWS D r. William C. Wimley, professor of biochemistry at Tulane University School of Medicine, has been named the 2012-2013 Oliver Fund Scholar to develop novel treatment alternatives using peptides for the global epidemic of drug-resistant bacterial infections. Tens of thousands of deaths in the United States alone are caused by bacterial infections that resist treatment by the usual chemical antibiotics, according to Wimley. As chemical antibiotics become ineffective, new approaches are desperately needed, he says. Wimleys laboratory will research the use of antimicrobial peptides, which have been investigated since the 1980s, as the basis for new drugs to treat drug-resistant bacteria. Peptides are molecules comprised of between two and 50 amino acids bonded together. Insulin and other hormones are peptides. Antimicrobial peptides are those that have been observed to act against bacteria. Although some antimicrobial peptides exhibit drawbacks including toxicity at high concentrations, loss of effectiveness in blood or plasma, rapid degradation and lack of high solubility, they have the distinct advantage that bacteria do not develop resistance to them. Wimleys research is targeted to identifying useful antimicrobial peptides that will function effectively in patients, have no toxicity for human cells, are simple and inexpensive to manufacture and will remain in blood or plasma for a long time. His laboratory will develop new methods for screening large numbers of alternate peptides to ?nd ones with these desirable qualities. Screening will be carried out in mixtures of bacteria and concentrated human erythrocytes red blood cells to identify antimicrobial peptides with the properties required of systemic anti-infective drugs, Wimley says. Peptides with these properties could lead to a new treatment option for drug-resistant bacterial infection. PIONEERING PEPTIDE RESEARCH MAY TACKLE ANTIBIOTIC-RESISTANT DISEASE Biochemistry professor Dr. William C. Wimley will study new treatment alternatives for drug-resistant bacterial infections, thanks to a $40,000 grant received through Tulanes Oliver Fund research competition. RESEARCH PRIZE TULANE TO DOUBLE CLINICAL TRIALS IN NEW FACILITYT ulane has almost tripled the size of patient treatment areas in a newly renovated Of?ce of Clinical Research within the Tidewater Building. The new Clinical Translational Unit is expected to more than double the capacity for clinical trials within the School of Medicine. The 17th-?oor Clinical Translational Unit has grown from three treatment areas to eight, including an infusion room, a multi-bed blood-draw area, a pediatric treatment room and space for minimally invasive procedures. Funding for the project came from Tulanes portion of a $20 million National Institutes of Health grant supporting biomedical research in the state through the newly created Louisiana Clinical and Translational Science (LA CaTS) Center. We are easily going to double our clinical trial portfolio over the next year or two, and that is all because of this infrastructure, says Tulane cardiologist Dr. Patrice Delafontaine, co-principal investigator for the LA CaTS grant. I think it increases our visibility nationally in a major way, frankly. We are getting more requests to do NIH-sponsored trials. The facility also allows Tulane researchers to better coordinate and collaborate with other partners in the LA CaTS program, including the Pennington Biomedical Research Center and Louisiana State University, Delafontaine says. There are roughly 50 trials underway with several more expected to begin before the end of the year, says Roberta McDuf?e, LA CaTS facilitator and director of clinical research for Endocrine and Cardiology. Dr. Patrice Delafontaine, co-principal investigator, in the Clinical Translational Unit pediatric treatment room.</p> <UL><LI><a href="http://www.mzines.net/publication/297/wqtaigylu/1/1/">Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/2/2/">Inside-Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/3/3/">Page-3</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/4/4/">Page-4</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/5/5/">Page-5</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/6/6/">Page-6</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/7/7/">Page-7</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/8/8/">Page-8</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/9/9/">Page-9</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/10/10/">Page-10</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/11/11/">Page-11</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/12/12/">Page-12</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/13/13/">Page-13</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/14/14/">Page-14</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/15/15/">Page-15</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/16/16/">Page-16</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/17/17/">Page-17</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/18/18/">Page-18</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/19/19/">Page-19</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/20/20/">Page-20</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/21/21/">Page-21</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/22/22/">Page-22</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/23/23/">Page-23</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/24/24/">Page-24</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/25/25/">Page-25</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/26/26/">Page-26</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/27/27/">Page-27</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/28/28/">Page-28</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/29/29/">Page-29</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/30/30/">Page-30</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/31/31/">Page-31</a></LI> <LI><a href="http://www.mzines.net/publication/297/wqtaigylu/32/32/">Back-Cover</a></LI> <LI><a href="http://www.mzines.net/publications/297/x/sitemap.xml" target="_blank">site map</a></LI> </UL>

 

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