<P>L LAMINITIS DOES NOT DISCRIMINATE. It attacks without regard for breed, size, sex or age of horses. As many as 2 percent of the U.S. equine population develops laminitis each year. And perhaps most perplexing is the fact that the disease can result from many different conditions. Bogged down by the multitude of causes that lead to the development of laminitis, Samuel Black, a veterinary professor at the University of Massachusetts, turned instead to studying the progression to end-stage laminitis – what ends up happening regard- less of what kicks off the laminitic episode. Understanding that, Black came to believe, was where healing therapies would be best targeted. Black and his research team initially began exploring the contribution of inflam- mation and ischemia reperfusion injury (injury that occurs when oxygen returns to tissue after a period of oxygen deficiency). In dissecting the biochemistry and molecular biology of the damaged laminae, I began to recognize patterns of gene and protein expression that were characteristic of end-stage disease, and these actually end up being in the laminae of laminitic horses irrespective of disease etiology, he explained. HOOFING THE COST OF RESEARCH Researchers work to unlock the mysteries of laminitis. By Jennifer K. Hancock Q-RACING JOURNAL SEPTEMBER 2013 85 </p> <UL><LI><a href="http://www.mzines.net/publication/335/josgoiuzx/1/1/">Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/2/2/">Inside-Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/3/3/">Page-3</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/4/4/">Page-4</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/5/5/">Page-5</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/6/6/">Page-6</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/7/7/">Page-7</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/8/8/">Page-8</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/9/9/">Page-9</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/10/10/">Page-10</a></LI> <LI><a href="http://www.mzines.net/publication/335/josgoiuzx/11/11/">Page-11</a></LI> <LI><a 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