<P>Spring 2014 | UCSF MAGAZINE47 Michael Marlettas father quashed his request for a chem- istry set, afraid his young son would blow up the house. So Marletta ordered a few chemi- cals from the pharmacy and mixed them up in the basement. While his irrepressible curios- ity got him in trouble, it also sparked a remarkable career exploring the intersection of chemistry and biology. As a UCSF doctoral student, work- ing in the lab of George Kenyon, PhD, Marletta pursued a growing fascination with enzymes. His research accelerated during stints on the faculty at the Massachusetts Institute of Technology, the University of Michigan, and UC Berkeley, where he chaired the chemistry department. Along the way, he made a pioneering discovery regarding the role of nitric oxide – a critical player in communication among cells – and received a MacArthur Foundation Fellowship, a prize popularly referred to as a genius grant. His contributions have also earned him top scientific accolades, includ- ing election to the Institute of Medicine, the American Academy of Arts and Sciences, and the National Academy of Sciences. In 2012, he assumed the presidency of the Scripps Research Institute. BIOLOGY BUZZ: I majored in chemistry in college and thought biology was a waste of time. I took a required biology course during the summer to get it out of the way. It was taught from a very physical perspective, and I realized biology was a much better chemist than humans would ever be. UCSF KNOCKS: While looking for graduate programs, I found chemistry departments paying lip service to biology, and biochemis- try departments that didnt seem chemical enough. My undergrad research mentor, Jerry Supple, met a new faculty member in the pharmaceutical chemistry depart- ment at UCSF, Neal Castagnoli. Castagnoli wrote me a two-and- a-half-page letter, telling me why UCSF would be a good place for me. I didnt get too many letters from faculty at big research univer- sities, so I applied! ACADEMIC MAVERICKS: The department was way ahead of the curve in mixing people who were thinking about biology from a chemical perspective with chemists. Tom James, Peter Kollman, George Kenyon, and Tack Kuntz had recently joined the faculty. The students were also different – they were primarily grounded in organic chemistry but interested in biol- ogy. It was an exciting time. PROFESSORIAL PATH: The biotech industry was just taking root when I graduated. But I had always wanted a career in academia. There are two reasons: I never liked having a boss, and its where you could do research and pursue whatever you were interested in. LEADING SCIENTISTS AND SCRIPPS: We want faculty who are smart and fiercely indepen- dent, because doing science is a tough business – as tough as its ever been.... I enjoy the chal- lenge of getting a large group of researchers to come together through a common vision. I also spend a lot of time talking to people who arent scientists about what we do. Its more important than ever to con- vince the public, in the face of diminishing federal resources, how important those resources are for ultimately delivering the highest quality health care in the United States. FROM THE ARCHIVES Laboratory of Experimental Oncology, 1950s. The Graduate Division, which was established in 1961, today oversees PhDs and postdocs who conduct cancer research in labs all across UCSF. PHOTOS THIS SPREAD: ©MICHAEL BALDERAS, COURTESY OF THE SCRIPPS RESEARCH INSTITUTE; ELISABETH FALL; UCSF ARCHIVES & SPECIAL COLLECTIONS MICHAEL MARLETTA, PhD 78 UCSF Graduate Program: Pharmaceutical Chemistry Hometown: Rochester, N.Y. Now: La Jolla, Calif. Position: President and CEO, Scripps Research Institute Hobbies: Cooking, wine</p> <UL><LI><a href="http://www.mzines.net/publication/618/aelvmorax/1/1/">Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/2/2/">Inside-Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/3/3/">Page-1</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/4/4/">Page-2</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/5/5/">Page-3</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/6/6/">Page-4</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/7/7/">Page-5</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/8/8/">Page-6</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/9/9/">Page-7</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/10/10/">Page-8</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/11/11/">Page-9</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/12/12/">Page-10</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/13/13/">Page-11</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/14/14/">Page-12</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/15/15/">Page-13</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/16/16/">Page-14</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/17/17/">Page-15</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/18/18/">Page-16</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/19/19/">Page-17</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/20/20/">Page-18</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/21/21/">Page-19</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/22/22/">Page-20</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/23/23/">Page-21</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/24/24/">Page-22</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/25/25/">Page-23</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/26/26/">Page-24</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/27/27/">Page-25</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/28/28/">Page-26</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/29/29/">Page-27</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/30/30/">Page-28</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/31/31/">Page-29</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/32/32/">Page-30</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/33/33/">Page-31</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/34/34/">Page-32</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/35/35/">Page-33</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/36/36/">Page-34</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/37/37/">Page-35</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/38/38/">Page-36</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/39/39/">Page-37</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/40/40/">Page-38</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/41/41/">Page-39</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/42/42/">Page-40</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/43/43/">Page-41</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/44/44/">Page-42</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/45/45/">Page-43</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/46/46/">Page-44</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/47/47/">Page-45</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/48/48/">Page-46</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/49/49/">Page-47</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/50/50/">Page-48</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/51/51/">Page-49</a></LI> <LI><a href="http://www.mzines.net/publication/618/aelvmorax/52/52/">Back-Cover</a></LI> <LI><a href="http://www.mzines.net/publications/618/x/sitemap.xml" target="_blank">site map</a></LI> </UL>

 

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