<P>chance to be more introspective and yet look at the scienti?c directions well beyond the next report deadline or the interminable wait for the next shipment of supplies. Being able to step back and look forward has been refreshing and yet o?ers new intellectual challenges. These exciting, frustrating, stimulating, and often di?cult years of work- ing overseas have taught me that science is truly a global collaboration. Whatever you do individually at the bench or in the ?eld is connected – it builds on the work of those that came before, and others will build on what you do long after. Living and working in remote and challenging locations highlights this global integration. Looking back at the twenty years since I ?rst arrived in Cairo and fast-forwarding through Bangkok and to Guatemala, some key lessons stand out: You will not have all the answers. In fact, you probably will not even know the questions. Listen and learn, then apply what you know. Embrace and understand the culture and people where you work and live. The pace and scope of science vary by place and the people; in essence, the science takes on the ?avor of the culture. At the same time, do not forget where you came from – that is what got you here in the ?rst place. Take advantage of opportunities and the rare occurrence of good luck, but there is no substitute for hard work (and a lot of it). Do not compromise your standards, but whatever you try to accomplish, make it sustainable – something that can be main- tained and improved after you are gone. Do not be afraid to make decisions, and if you ?nd a problem, make sure you can also propose a solution (or more than one) – always have some options. Accept that you will fail sometimes. Take on the biggest, most di?cult challenges – these will force you to be better than your- self and look outside of yourself for answers. 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