<P>Page 4 Today, it is easy to become complacent with modern day comforts; instant communication, air conditioned homes, medicines that prevent or cure your ailments. For many, the threats are far away, the diseases are rare, and science is ahead of the curve. It is only after personally confronted with disease, or caught in the tragic events of a catastrophe that we realize the limits of our collective knowledge, and the critical and often desperate need to know more. Drug resistance, epidemics of emerging infectious diseases as well as chronic diseases, thrust each of us to the realization that we have much to learn about mother nature, and for science to get ahead of the curve, we must go to those far-away, hard places, to learn what we do not know, and study it. The modern day is in fact far from comfortable for most, and progress for all, begins with science, in those hard places. And we often make friends along the way. JASON RAO These hard places are isolated with ever increasing political barriers that fuel misperception, steadily replacing generations of friendship with misunderstanding and hostility. This second issue of Cultures, on Science in Hard Places, is a topic that is central to our vision for the magazine, illustrating how science can happen in the most challeng- ing environments—an advance- ment of our collective knowledge as well as our common under- standing of one another. Science sets aside politics to solve shared problems. Something we can all agree upon. What is a hard place? There is no single de?nition, but here we let the authors illustrate them. From geographic boundaries and political barriers to resource con- straints and unstable environ- ments, they form partnerships and together forge a pathway for </p> <UL><LI><a href="http://www.mzines.net/publication/643/colfslwvw/1/1/">Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/2/2/">Inside-Front-Cover</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/3/3/">Page-1</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/4/4/">Page-2</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/5/5/">Page-3</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/6/6/">Page-4</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/7/7/">Page-5</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/8/8/">Page-6</a></LI> <LI><a href="http://www.mzines.net/publication/643/colfslwvw/9/9/">Page-7</a></LI> <LI><a 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